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Version: 17.06d (Release date: 2017-06-26)
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Isoniazid (Code C600)

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Terms & Properties

Preferred Name: Isoniazid

Definition: A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. (NCI04)

Label: Isoniazid

NCI Thesaurus Code: C600 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0022209  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Isonicotinic Acid Hydrazide
Isonicotinyl Hydrazine

External Source Codes: 
CAS Registry Number 54-85-3 (see NLM ChemIDplus info)
ChEBI ID CHEBI:6030 (see ChEBI info)
NSC Code 9659 (see NCI DTP info)
PDQ Closed Trial Search ID 39484
PDQ Open Trial Search ID 39484 (check for NCI PDQ open clinical trial info)
UMLS CUI C0022209

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C6H7N3O
code C600
Contributing_Source FDA
Legacy_Concept_Name Isoniazid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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