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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interleukin-6 (Code C591)

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Terms & Properties

Preferred Name: Recombinant Interleukin-6

Definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-6 (IL-6) with antiapoptotic, proinflammatory, antiinflammatory, proproliferative and proangiogenic activities. IL-6 binds to its receptor (IL-6R), activating a receptor-CD130 receptor complex; the CD130 portion of the complex is a signal transduction protein that activates JAK kinases and Ras-mediated signaling pathways, which in turn activate downstream signaling pathways, resulting in the activation of various transcription factors (STAT, ELK-1, NF-IL-6, etc.) and gene transcription. The physiological effects of IL-6 are complex and varied and include hematopoietic, pyrogenic and thermogenic, proinflammatory, antiinflammatory, proproliferative (anti-apoptotic), and angiogenic effects.

NCI-GLOSS Definition: One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-6 is made mainly by some T lymphocytes. It causes B lymphocytes to make more antibodies and also causes fever by affecting areas of the brain that control body temperature. Interleukin-6 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-6 is a type of cytokine.

Display Name: Recombinant Interleukin-6

Label: Recombinant Interleukin-6

NCI Thesaurus Code: C591 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1527132  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B-Cell Stimulatory Factor-2
B Cell Differentiation Factor 2
Hepatocyte Stimulating Factor
Hybridoma Growth Factor
IFN Beta 2
Myeloid Differentiation Inducing Protein
Plasmacytoma Growth Factor
Recombinant Interleukin-6

External Source Codes: 
PDQ Closed Trial Search ID 41474
PDQ Open Trial Search ID 41474 (check for NCI PDQ open clinical trial info)
UMLS CUI C1527132

Other Properties:
     Name Value (qualifiers indented underneath)
code C591
Contributing_Source CTRP
Legacy_Concept_Name Therapeutic_Interleukin-6
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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