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Version: 16.11d (Release date: 2016-11-28)
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Binetrakin (Code C589)

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Terms & Properties

Preferred Name: Binetrakin

Definition: A recombinant agent chemically identical to or similar to the endogenous cytokine interleukin-4 (IL-4). Produced primarily by activated T-cells, IL-4 binds to and activates its cell-surface receptor, stimulating the proliferation and differentiation of activated B-cells and enhancing their ability to present antigens to T-cells. As a potential immunotherapeutic agent, recombinant IL-4 also augments the effects of other cytokines on dendritic cells (DC), cytotoxic T lymphocytes (CTL), and tumor-infiltrating lymphocytes (TIL).

Label: Binetrakin

NCI Thesaurus Code: C589 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1522540  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B-Cell Growth Factor
B-Cell Stimulating Factor
B-Cell Stimulatory Factor 1
BCGF
BCSF 1
BINETRAKIN
Binetrakin
B Cell Proliferating Factor
IL-4
Interleukin-4
Mast Cell Growth Factor-2
MCGF 2
Recombinant Human IL-4
RHIL-4
T-Cell Growth Factor 2

External Source Codes: 
CAS Registry Number 207137-56-2 (see NLM ChemIDplus info)
FDA UNII Code 751635Z921
NSC Code 618085 (see NCI DTP info)
NSC Code 620211 (see NCI DTP info)
PDQ Closed Trial Search ID 39324
PDQ Open Trial Search ID 39324 (check for NCI PDQ open clinical trial info)
UMLS CUI C1522540

Other Properties:
Name Value (qualifiers indented underneath)
code C589
Contributing_Source FDA
Legacy_Concept_Name Therapeutic_Interleukin-4
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C589

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