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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interleukin-3 (Code C588)

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Terms & Properties

Preferred Name: Recombinant Interleukin-3

Definition: A recombinant form of interleukin-3, a cytokine produced by activated T-cells and mast cells involved in intercellular communication, hematopoiesis, and inflammation. IL-3 binds and activates specific receptors on hematopoietic cells and in the nervous system, triggering expression of specific genes via the Ras signaling pathway and through Jak2 activation. This agent stimulates the proliferation of pluripotent hematopoietic progenitor cells.

Label: Recombinant Interleukin-3

NCI Thesaurus Code: C588 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1527130  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Colony-Stimulating Factor 2 Alpha
Eosinophil-Mast Cell Growth-Factor
Erythrocyte Burst-Promoting Factor
Mast-Cell Colony-Stimulating Factor
Multipotential Colony-Stimulating Factor
Recombinant Interleukin-3

External Source Codes: 
NSC Code 641115 (see NCI DTP info)
PDQ Closed Trial Search ID 38970
PDQ Open Trial Search ID 38970 (check for NCI PDQ open clinical trial info)
UMLS CUI C1527130

Other Properties:
     Name Value (qualifiers indented underneath)
code C588
Legacy_Concept_Name Therapeutic_Interleukin-3
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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