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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interleukin-1-beta (Code C585)

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Terms & Properties

Preferred Name: Recombinant Interleukin-1-beta

Definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine interleukin 1 (IL-1)-beta. Produced by monocytes and activated macrophages, endogenous mature IL-1 is generated through proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE). This agent promotes angiogenesis, fibroblast proliferation, and neutrophil chemotaxis; it also regulates the functions of lymphocytes and epithelial cells and is involved in the 'acute phase response' to infection. (NCI04)

Label: Recombinant Interleukin-1-beta

NCI Thesaurus Code: C585 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1522432  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Interleukin-1-beta

External Source Codes: 
PDQ Closed Trial Search ID 40793
PDQ Open Trial Search ID 40793 (check for NCI PDQ open clinical trial info)
UMLS CUI C1522432

Other Properties:
     Name Value (qualifiers indented underneath)
code C585
Legacy_Concept_Name Recombinant_Interleukin-1-beta
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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