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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interferon (Code C584)

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Terms & Properties

Preferred Name: Recombinant Interferon

Definition: One of a group of recombinant therapeutic glycoprotein cytokines with antiviral, anti-proliferative, and immunomodulating activities. Interferons bind to specific cell-surface receptors, leading to the transcription and translation of genes with interferon-specific response elements (ISREs). The resultant proteins mediate many complex effects, ultimately leading to inhibition of viral protein synthesis and cellular growth, alteration of cellular differentiation, interference with oncogene expression, activation of natural killer cells, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity. The production of endogenous interferons is induced in response to foreign agents such as bacteria, viruses and parasites and to tumor cells.

Label: Recombinant Interferon

NCI Thesaurus Code: C584 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1522537  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Human Leukocyte Interferon
Human Lymphoblastoid Interferon
Human lymphoblastoid interferon
IFN
Interferons
Recombinant Interferon

External Source Codes: 
CAS Registry Number 9008-1-11 (see NLM ChemIDplus info)
NSC Code 339140 (see NCI DTP info)
PDQ Closed Trial Search ID 40863
PDQ Open Trial Search ID 40863 (check for NCI PDQ open clinical trial info)
UMLS CUI C1522537

Other Properties:
     Name Value (qualifiers indented underneath)
code C584
Legacy_Concept_Name Therapeutic_Interferon
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C584

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