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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interferon Gamma (Code C583)

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Terms & Properties

Preferred Name: Recombinant Interferon Gamma

Definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)

Display Name: Recombinant Interferon Gamma

Label: Recombinant Interferon Gamma

NCI Thesaurus Code: C583 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0813623  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Gamma-Interferon
Gamma Interferon-SCH
Gamma Interferon (GEN)
Ginterferon
IFN-g
Interferon, Gamma
Interferon Gamma
Interferon Gamma (BIO)
Recombinant Interferon Gamma

External Source Codes: 
CAS Registry Number 82115-62-6 (see NLM ChemIDplus info)
NSC Code 600662 (see NCI DTP info)
NSC Code 635256 (see NCI DTP info)
PDQ Closed Trial Search ID 40469
PDQ Open Trial Search ID 40469 (check for NCI PDQ open clinical trial info)
UMLS CUI C0813623

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic granulomatous disease; Osteopetrosis
code C583
Contributing_Source CTRP
Legacy_Concept_Name Therapeutic_Interferon_Gamma
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C583

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