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Version: 17.06d (Release date: 2017-06-26)
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Indomethacin (Code C576)

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Terms & Properties

Preferred Name: Indomethacin

Definition: A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)

NCI-GLOSS Definition: A drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs. It is a type of nonsteroidal anti-inflammatory drug (NSAID).

Display Name: Indomethacin

Label: Indomethacin

NCI Thesaurus Code: C576 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0021246  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid

External Source Codes: 
CAS Registry Number 53-86-1 (see NLM ChemIDplus info)
ChEBI ID CHEBI:49662 (see ChEBI info)
NSC Code 77541 (see NCI DTP info)
PDQ Closed Trial Search ID 39489
PDQ Open Trial Search ID 39489 (check for NCI PDQ open clinical trial info)
UMLS CUI C0021246

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Dysmennorhea; Inflammatory disorders; Pain
Chemical_Formula C19H16ClNO4
code C576
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Indomethacin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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