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Version: 16.10e (Release date: 2016-10-31)
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Imipenem (Code C570)

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Terms & Properties

Preferred Name: Imipenem

Definition: A broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This inactivation results in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive and gram-negative organisms and is stable in the presence of beta-lactamases. (NCI05)

NCI-GLOSS Definition: An antibiotic drug used to treat severe or very resistant infection. It belongs to the family of drugs called carbapenems.

Label: Imipenem

NCI Thesaurus Code: C570 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0020933  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Imipemide
IMIPENEM
Imipenem
imipenem
MK-0787

External Source Codes: 
CAS Registry Number 74431-23-5 (see NLM ChemIDplus info)
FDA UNII Code 71OTZ9ZE0A
ChEBI ID CHEBI:51799 (see ChEBI info)
NSC Code 717864 (see NCI DTP info)
PDQ Closed Trial Search ID 42116
PDQ Open Trial Search ID 42116 (check for NCI PDQ open clinical trial info)
UMLS CUI C0020933

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C12H17N3O4S.H2O
code C570
Contributing_Source FDA
Legacy_Concept_Name Imipenem
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C570

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