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Version: 17.06d (Release date: 2017-06-26)
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Idoxuridine (Code C563)

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Terms & Properties

Preferred Name: Idoxuridine

Definition: An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is incorporated into DNA and disrupts viral replication. Upon oral administration of the idoxuridine prodrug ropidoxuridine and hepatic conversion by aldehyde oxidase into idoxuridine, this agent incorporates into DNA and sensitizes cells to ionizing radiation by increasing DNA strand breaks.

NCI-GLOSS Definition: A drug that reduces the risk of cancer cell growth by interfering with the cells' DNA.

Label: Idoxuridine

NCI Thesaurus Code: C563 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0020811  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil
1-beta-D-2'-Deoxyribofuranosyl-5-iodouracil
1beta-D-2'-Deoxyribofuranosyl-5-iodouracil
2'-Deoxy-5-iodouridine
5-iodo-2'-deoxyuridine
5-Iodo-2'-deoxyuridine
5-Iododeoxyuridine
5-IUdR
Dendrid
Herplex
Idexur
Idoxene
IDOXURIDINE
Idoxuridine
idoxuridine
IDU
Idulea
IDUR
IdURD
Iduridin
Iododeoxyuridine
IUdR
IUDR
Kerecid
SKF 14287
Stoxil
Uracil, 5-iodo-1-(2-deoxy-beta-D-ribofuranosyl)-
Uridine, 2'-deoxy-5-iodo-
Virudox

External Source Codes: 
CAS Registry Number 54-42-2 (see NLM ChemIDplus info)
FDA UNII Code LGP81V5245
ChEBI ID CHEBI:147675 (see ChEBI info)
NSC Code 39661 (see NCI DTP info)
PDQ Closed Trial Search ID 39481
PDQ Open Trial Search ID 39481 (check for NCI PDQ open clinical trial info)
UMLS CUI C0020811

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H11IN2O5
code C563
Contributing_Source FDA
Legacy_Concept_Name Idoxuridine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C563

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