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Version: 17.06d (Release date: 2017-06-26)
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Idarubicin (Code C562)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Idarubicin

Definition: A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes with the activity of topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds.

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called antitumor antibiotics.

Display Name: Idarubicin

Label: Idarubicin

NCI Thesaurus Code: C562 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0020789  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside
(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione
4-Demethoxydaunomycin
4-demethoxydaunorubicin
4-Demethoxydaunorubicin
4-DMDR
Idarubicin
IDARUBICIN
idarubicin

External Source Codes: 
CAS Registry Number 58957-92-9 (see NLM ChemIDplus info)
FDA UNII Code ZRP63D75JW
ChEBI ID CHEBI:42068 (see ChEBI info)
PDQ Closed Trial Search ID 39753
PDQ Open Trial Search ID 39753 (check for NCI PDQ open clinical trial info)
UMLS CUI C0020789

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute myeloid leukemia; acute nonlymphocytic leukemia
Chemical_Formula C26H27NO9
code C562
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Idarubicin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C562

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