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Version: 17.06d (Release date: 2017-06-26)
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Ibuprofen (Code C561)

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Terms & Properties

Preferred Name: Ibuprofen

Definition: A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)

NCI-GLOSS Definition: A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID).

Display Name: Ibuprofen

Label: Ibuprofen

NCI Thesaurus Code: C561 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0020740  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(.+ -.)-p-Isobutylhydratropic acid
Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)-
p-Isobutylhydratropic Acid
p-Isobutylhydratropic acid

External Source Codes: 
CAS Registry Number 15687-27-1 (see NLM ChemIDplus info)
ChEBI ID CHEBI:5855 (see ChEBI info)
NSC Code 256857 (see NCI DTP info)
PDQ Closed Trial Search ID 40475
PDQ Open Trial Search ID 40475 (check for NCI PDQ open clinical trial info)
UMLS CUI C0020740

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C13H18O2
code C561
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ibuprofen
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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