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Version: 17.06d (Release date: 2017-06-26)
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Hydroxyurea (Code C560)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Hydroxyurea

Definition: A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called antimetabolites.

Display Name: Hydroxyurea

Label: Hydroxyurea

NCI Thesaurus Code: C560 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0020402  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Droxia
Hydrea
Hydroxycarbamide
Hydroxyurea
HYDROXYUREA
hydroxyurea
Litalir
Onco-carbide
Onco-Carbide
Oncocarbide
Oxeron
SQ-1089
SQ 1089
Syrea
WR 83799

External Source Codes: 
CAS Registry Number 127-07-1 (see NLM ChemIDplus info)
FDA UNII Code X6Q56QN5QC
ChEBI ID CHEBI:44423 (see ChEBI info)
NSC Code 32065 (see NCI DTP info)
PDQ Closed Trial Search ID 40685
PDQ Open Trial Search ID 40685 (check for NCI PDQ open clinical trial info)
UMLS CUI C0020402

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic Myelogenous Leukemia; Head and Neck Cancer; Malignant Melanoma; Ovarian Carcinoma; Sickle Cell Anemia; Adjuvant in Retroviral Therapy.
Chemical_Formula CH4N2O2
code C560
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Hydroxyurea
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C560

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