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Version: 16.11d (Release date: 2016-11-28)
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Hydroxychloroquine (Code C557)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Hydroxychloroquine

Definition: A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines. As a lysosomotropic agent, hydroxychloroquine raises intralysosomal pH, impairing autophagic protein degradation; hydroxychloroquine-mediated accumulation of ineffective autophagosomes may result in cell death in tumor cells reliant on autophagy for survival. In addition, this agent is highly active against the erythrocytic forms of P. vivax and malariae and most strains of P. falciparum but not the gametocytes of P. falciparum.

NCI-GLOSS Definition: A substance that decreases immune responses in the body. It is used to treat some autoimmune diseases, and is being studied as a treatment for graft-versus-host disease. Hydroxychloroquine belongs to the family of drugs called antiprotozoals.

Display Name: Hydroxychloroquine

Label: Hydroxychloroquine

NCI Thesaurus Code: C557 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0020336  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hydroxychloroquine
HYDROXYCHLOROQUINE
hydroxychloroquine

External Source Codes: 
CAS Registry Number 118-42-3 (see NLM ChemIDplus info)
FDA UNII Code 4QWG6N8QKH
PDQ Closed Trial Search ID 38571
PDQ Open Trial Search ID 38571 (check for NCI PDQ open clinical trial info)
UMLS CUI C0020336

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Malaria; Rheumatoid arthritis
Chemical_Formula C18H26ClN3O
code C557
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Hydroxychloroquine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C557

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