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National Cancer Institute
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Version: 17.10e (Release date: 2017-10-30)
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Hycanthone (Code C550)

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Terms & Properties

Preferred Name: Hycanthone

Definition: A thioxanthene derivative of lucanthone with anti-schistosomal activity and potential antineoplastic activity. Hycanthone interferes with parasite nerve function, resulting in parasite paralysis and death. This agent also intercalates into DNA and inhibits RNA synthesis in vitro. (NCI04)

Label: Hycanthone

NCI Thesaurus Code: C550 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0020207  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hycanthone Mesylate
Hycanthone mesylate

External Source Codes: 
CAS Registry Number 3105-97-3 (see NLM ChemIDplus info)
ChEBI ID CHEBI:52768 (see ChEBI info)
NSC Code 134434 (see NCI DTP info)
PDQ Closed Trial Search ID 39477
PDQ Open Trial Search ID 39477 (check for NCI PDQ open clinical trial info)
UMLS CUI C0020207

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H24N2O2S
code C550
Contributing_Source FDA
Legacy_Concept_Name Hycanthone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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