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Version: 17.12d (Release date: 2017-12-26)
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Pibenzimol (Code C546)

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Terms & Properties

Preferred Name: Pibenzimol

Definition: A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I, and DNA polymerase, thereby preventing DNA replication. This agent prolongs the G2 phase of the cell cycle and initiates apoptosis in tumor cells. (NCI04)

Label: Pibenzimol

NCI Thesaurus Code: C546 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0019832  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hoe 33258
HOE 33258
Hoechst 33258
Hoechst Dye 33258
Hoechst dye 33258
Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, Trihydrochloride
Phenol, p-[5-[5-(4-methyl-1-piperazinyl)-2-benzimidazolyl]-2- benzimidazolyl]-, Trihydrochloride
Pibenzimol Hydrochloride

External Source Codes: 
CAS Registry Number 23491-45-4 (see NLM ChemIDplus info)
ChEBI ID CHEBI:52082 (see ChEBI info)
NSC Code 322921 (see NCI DTP info)
PDQ Closed Trial Search ID 39193
PDQ Open Trial Search ID 39193 (check for NCI PDQ open clinical trial info)
UMLS CUI C0019832

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H24N6O
code C546
Contributing_Source FDA
Legacy_Concept_Name Pibenzimol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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