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Version: 17.06d (Release date: 2017-06-26)
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Altretamine (Code C544)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Altretamine

Definition: A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called alkylating agents.

Label: Altretamine

NCI Thesaurus Code: C544 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0019453  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2,4,6-Tris(dimethylamino)-s-triazine
2,4,6-tris(dimethylamino)-s-triazine
altretamine
ALTRETAMINE
Altretamine
ENT-50852
ENT 50852
Hemel
Hexalen
Hexaloids
Hexamethylamine
Hexamethylmelamine
Hexastat
Hexinawas
HMM
HXM
N,n,n',N"N"-hexamethyl-1,3,5,-triazine-2,4,6,-triamine
N,N,N',N',N",N"-hexamethyl-1,3,5-triazine-2,4,6-triamine
RB-1515
s-Triazine, 2,4,6-tris(dimethylamino)-
WR-95704

External Source Codes: 
CAS Registry Number 645-05-6 (see NLM ChemIDplus info)
FDA UNII Code Q8BIH59O7H
ChEBI ID CHEBI:24564 (see ChEBI info)
NSC Code 13875 (see NCI DTP info)
PDQ Closed Trial Search ID 39475
PDQ Open Trial Search ID 39475 (check for NCI PDQ open clinical trial info)
UMLS CUI C0019453

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H18N6
code C544
Contributing_Source FDA
Legacy_Concept_Name Altretamine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C544

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