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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Heparin (Code C539)

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Terms & Properties

Preferred Name: Heparin

Definition: A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots.

NCI-GLOSS Definition: A substance that slows the formation of blood clots. Heparin is made by the liver, lungs, and other tissues in the body and can also made in the laboratory. Heparin may be injected into muscle or blood to prevent or break up blood clots. It is a type of anticoagulant.

Display Name: Heparin

Label: Heparin

NCI Thesaurus Code: C539 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0019134  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 9005-49-6 (see NLM ChemIDplus info)
FDA UNII Code T2410KM04A
ChEBI ID CHEBI:28304 (see ChEBI info)
PDQ Closed Trial Search ID 40848
PDQ Open Trial Search ID 40848 (check for NCI PDQ open clinical trial info)
UMLS CUI C0019134

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Conditions requiring anticoagulation (thrombosis; embolism)
Chemical_Formula (C14H18NO11)n.2(C12H16NO13S)n.3HO3S
code C539
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Heparin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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