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Version: 17.06d (Release date: 2017-06-26)
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Haloperidol (Code C537)

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Terms & Properties

Preferred Name: Haloperidol

Definition: A phenylbutylpiperadine derivative with antipsychotic, neuroleptic, and antiemetic activities. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain, thereby eliminating dopamine neurotransmission and leading to antidelusionary and antihallucinagenic effects. Antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) accounts for its antiemetic activity.

NCI-GLOSS Definition: A drug used to treat certain mental and neurological disorders. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of antiemetic and a type of antipsychotic.

Display Name: Haloperidol

Label: Haloperidol

NCI Thesaurus Code: C537 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0018546  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
Haldol
Haloperidol
HALOPERIDOL
haloperidol
McN-JR-1625
R-1625
R 1625

External Source Codes: 
CAS Registry Number 52-86-8 (see NLM ChemIDplus info)
FDA UNII Code J6292F8L3D
ChEBI ID CHEBI:5613 (see ChEBI info)
NSC Code 170973 (see NCI DTP info)
PDQ Closed Trial Search ID 39474
PDQ Open Trial Search ID 39474 (check for NCI PDQ open clinical trial info)
UMLS CUI C0018546

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H23ClFNO2
code C537
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Haloperidol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C537

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