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Version: 17.06d (Release date: 2017-06-26)
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Octreotide Acetate (Code C53447)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Octreotide Acetate

Definition: The acetate salt of a synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone.

Display Name: Octreotide Acetate

Label: Octreotide Acetate

NCI Thesaurus Code: C53447 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0728977  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide Acetate
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hyroxymethyl)propyl]-L-cysteinamide, Cyclic (2->7)-disulfide, Acetate (Salt)
Longastatin
Longastatina
Octreotide Acetate
OCTREOTIDE ACETATE
Octreotide acetate
Samilstin
Sandostatin
Sandostatina
Sandostatine
Sandostatin Lar Depot
SMS 201-995
SMS 201-995 AC

External Source Codes: 
CAS Registry Number 79517-01-4 (see NLM ChemIDplus info)
FDA UNII Code 75R0U2568I
NSC Code 671663 (see NCI DTP info)
PDQ Closed Trial Search ID 38866
PDQ Open Trial Search ID 38866 (check for NCI PDQ open clinical trial info)
UMLS CUI C0728977

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acromegaly; Diarrhea
Chemical_Formula C49H66N10O10S2.C2H4O2
code C53447
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Octreotide_Acetate
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53447

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