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Version: 17.06d (Release date: 2017-06-26)
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Saponin-Cholesterol-Phospholipid Adjuvant (Code C53436)

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Terms & Properties

Preferred Name: Saponin-Cholesterol-Phospholipid Adjuvant

Definition: An adjuvant comprised of saponin, derived from the bark of Quillaia saponaria Molina, cholesterol and phospholipid with antigen-delivery and immunostimulatory activities. This saponin-based adjuvant in combination with various antigens, including those for human papilloma virus (HPV), hepatitis C virus (HCV), and the human cancer antigen NY-ESO-1, may result in potent antibody, CD4+ T-helper-cell, and CD8+ cytotoxic T-cell responses against the targeted antigen. In addition, this agent may reduce the amount of antigen necessary to induce an efficient immune response in the host.

Display Name: Saponin-Cholesterol-Phospholipid Adjuvant

Label: Saponin-Cholesterol-Phospholipid Adjuvant

NCI Thesaurus Code: C53436 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1529741  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Iscomatrix
Saponin-Cholesterol-Phospholipid Adjuvant

External Source Codes: 
PDQ Closed Trial Search ID 465382
PDQ Open Trial Search ID 465382 (check for NCI PDQ open clinical trial info)
UMLS CUI C1529741

Other Properties:
     Name Value (qualifiers indented underneath)
code C53436
Contributing_Source CTRP
Legacy_Concept_Name Saponin_Cholesterol_Phospholipid_Adjuvant
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53436

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