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Version: 17.06d (Release date: 2017-06-26)
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Vascular Endothelial Growth Factor Antisense Oligonucleotide (Code C53435)

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Terms & Properties

Preferred Name: Vascular Endothelial Growth Factor Antisense Oligonucleotide

Definition: An antisense oligonucleotide with potential antiangiogenesis activity. Vascular endothelial growth factor (VEGF) antisense oligonucleotide binds directly to binds VEGF A/C/D mRNA, leading to mRNA degradation and the inhibition of VEGF A-mediated angiogenesis and VEGF C/D-mediated lymphangiogenesis.

NCI-GLOSS Definition: A substance that has been studied in the treatment of cancer. It binds to the RNA for a protein called vascular endothelial growth factor (VEGF) that stimulates the growth of new blood vessels. Vascular endothelial growth factor-antisense oligonucleotide blocks the cell's ability to make VEGF, which may kill tumors that need new blood vessels to grow. It is a type of antisense oligonucleotide and a type of gene expression inhibitor.

Label: Vascular Endothelial Growth Factor Antisense Oligonucleotide

NCI Thesaurus Code: C53435 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1710619  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
vascular endothelial growth factor-antisense oligonucleotide
Vascular Endothelial Growth Factor Antisense Oligonucleotide
VEGF-AS
Veglin

External Source Codes: 
PDQ Closed Trial Search ID 465178
PDQ Open Trial Search ID 465178 (check for NCI PDQ open clinical trial info)
UMLS CUI C1710619

Other Properties:
     Name Value (qualifiers indented underneath)
code C53435
Legacy_Concept_Name Vascular_Endothelial_Cell_Growth_Factor_Antisense_Oligonucleotide
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53435

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