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Version: 17.06d (Release date: 2017-06-26)
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Diindolylmethane (Code C53434)

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Terms & Properties

Preferred Name: Diindolylmethane

Definition: A phytonutrient and plant indole found in cruciferous vegetables including broccoli, Brussels sprouts, cabbage, cauliflower and kale, with potential anti-androgenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown.

NCI-GLOSS Definition: A substance being studied in the treatment of prostate cancer and in the prevention of cervical cancer. Diindolylmethane is found in cruciferous vegetables like broccoli, brussels sprouts, cauliflower, cabbage, and kale. It is a type of plant indole.

Display Name: Diindolylmethane

Label: Diindolylmethane

NCI Thesaurus Code: C53434 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1100708  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3,3'-Diindolymethane
3,3'-Methylenebis-1H-indole
CCRIS 5806
Di-Indoly Methane
Diindolylmethane
diindolylmethane
DIM
DIM-Plus
DIMPRO

External Source Codes: 
CAS Registry Number 1968-05-4 (see NLM ChemIDplus info)
ChEBI ID CHEBI:50182 (see ChEBI info)
PDQ Closed Trial Search ID 462587
PDQ Open Trial Search ID 462587 (check for NCI PDQ open clinical trial info)
UMLS CUI C1100708

Other Properties:
     Name Value (qualifiers indented underneath)
code C53434
Contributing_Source CTRP
Legacy_Concept_Name Diindolylmethane
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53434

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