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Version: 17.06d (Release date: 2017-06-26)
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Yttrium Y-90-DOTA-Girentuximab (Code C53409)

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Terms & Properties

Preferred Name: Yttrium Y-90-DOTA-Girentuximab

Definition: A radioimmunoconjugate comprised of the chimeric monoclonal antibody cG250 conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with the beta-emitting radioisotope yttrium 90. The antibody moiety of yttrium 90 DOTA chimeric monoclonal antibody cG250 binds to renal cell carcinoma cells expressing the G250 antigen, thereby selectively delivering a cytotoxic dose of beta radiation.

Label: Yttrium Y-90-DOTA-Girentuximab

NCI Thesaurus Code: C53409 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1710703  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
90Y-DOTA-cG250
Yttrium-90 DOTA Conjugated Chimeric MoAb G250
Yttrium Y-90-DOTA-Girentuximab
Yttrium Y 90-DOTA-Chimeric Monoclonal Antibody cG250

External Source Codes: 
PDQ Closed Trial Search ID 465788
PDQ Open Trial Search ID 465788 (check for NCI PDQ open clinical trial info)
UMLS CUI C1710703

Other Properties:
     Name Value (qualifiers indented underneath)
code C53409
Legacy_Concept_Name Yttrium_Y_90_DOTA_Chimeric_Monoclonal_Antibody_cG250
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53409

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