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Version: 17.06d (Release date: 2017-06-26)
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Alfuzosin Hydrochloride (Code C53408)

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Terms & Properties

Preferred Name: Alfuzosin Hydrochloride

Definition: The hydrochloride salt of alfuzosin, a quinazoline compound with smooth muscle-relaxing activity. Alfuzosin selectively binds to and antagonizes post-synaptic alpha-1-adrenoreceptors in smooth muscle of the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra, initiating relaxation of smooth muscle and resulting in improvement of urine flow and the symptoms of benign prostatic hyperplasia (BPH). This agent also blocks alpha-1-adrenoreceptors in peripheral vascular smooth muscle, resulting in vasodilatation and a decrease in peripheral vascular resistance.

Label: Alfuzosin Hydrochloride

NCI Thesaurus Code: C53408 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0102130  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+/-)-N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide Monohydrochloride
(R,S)-N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino] propyl]tetrahydro-2-furancarboxamide Hydrochloride
Alfuzosin Hydrochloride
ALFUZOSIN HYDROCHLORIDE
SL 77499-10
Uroxatral

External Source Codes: 
CAS Registry Number 81403-68-1 (see NLM ChemIDplus info)
FDA UNII Code 75046A1XTN
ChEBI ID CHEBI:32286 (see ChEBI info)
PDQ Closed Trial Search ID 465648
PDQ Open Trial Search ID 465648 (check for NCI PDQ open clinical trial info)
UMLS CUI C0102130

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H27N5O4.ClH
code C53408
Contributing_Source FDA
Legacy_Concept_Name Alfuzosin_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53408

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