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Version: 17.06d (Release date: 2017-06-26)
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Iodine I-124 Girentuximab (Code C53407)

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Terms & Properties

Preferred Name: Iodine I-124 Girentuximab

Definition: A radioimmunoconjugate comprised of the chimeric monoclonal antibody G250 conjugated with the positron emitter iodine I 124. The antibody moiety of iodine I 124 chimeric monoclonal antibody G250 may bind to renal cell carcinoma (RCC) cells that express the RCC-associated antigen G250, allowing detection of tumor-localized iodine I 124 with positron emission tomography (PET). G250 is a cell surface tumor-associated antigen (TAA) that is found in the majority of renal cell carcinomas.

Display Name: Iodine I-124 Girentuximab

Label: Iodine I-124 Girentuximab

NCI Thesaurus Code: C53407 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383142  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
124I-cG250
124IcG250
GIRENTUXIMAB I-124
Iodine I-124 Girentuximab
Iodine I 124 Chimeric Monoclonal Antibody G250
I 124 MoAb cG250
Redectane

External Source Codes: 
CAS Registry Number 1011710-99-8 (see NLM ChemIDplus info)
FDA UNII Code P0I0FT82VK
PDQ Closed Trial Search ID 465493
PDQ Open Trial Search ID 465493 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383142

Other Properties:
     Name Value (qualifiers indented underneath)
code C53407
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Iodine_I_124_Chimeric_Monoclonal_Antibody_cG250
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53407

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