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Version: 17.06d (Release date: 2017-06-26)
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Citrulline (Code C53406)

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Terms & Properties

Preferred Name: Citrulline

Definition: A non-essential amino acid. In hepatocytes, L-citrulline is synthesized in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. L-citrulline is converted into L-arginine by the enzymes argininosuccinate synthetase and argininosuccinate lyase in the presence of L-aspartate and ATP. Subsequently, L-arginine is converted to nitric oxide by nitric oxide synthase and L-citrulline is regenerated as a by-product.

Label: Citrulline

NCI Thesaurus Code: C53406 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0008864  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Amino-5-(carbamoylamino)pentanoic Acid
CITRULLINE
Citrulline
L-Citrulline
N5-(Aminocarbonyl)-L-ornithine

External Source Codes: 
CAS Registry Number 372-75-8 (see NLM ChemIDplus info)
FDA UNII Code 29VT07BGDA
ChEBI ID CHEBI:16349 (see ChEBI info)
NSC Code 27425 (see NCI DTP info)
PDQ Closed Trial Search ID 464795
PDQ Open Trial Search ID 464795 (check for NCI PDQ open clinical trial info)
UMLS CUI C0008864

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C6H13N3O3
code C53406
Contributing_Source FDA
Legacy_Concept_Name Citrulline
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53406

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