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Version: 16.11d (Release date: 2016-11-28)
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Elacytarabine (Code C53401)

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Terms & Properties

Preferred Name: Elacytarabine

Definition: The lipophilic 5'-elaidic acid ester of the deoxycytidine analog cytosine arabinoside (cytarabine; Ara-C) with potential antineoplastic activity. As a prodrug, elacytarabine is converted intracellularly into cytarabine triphosphate by deoxycytidine kinase and subsequently competes with cytidine for incorporation into DNA, thereby inhibiting DNA synthesis. Compared to cytarabine, elacytarabine shows increased cellular uptake and retention, resulting in increased activation by deoxycytidine kinase to cytarabine triphosphate, decreased deamination and deactivation by deoxycytidine deaminase, and increased inhibition of DNA synthesis. This agent also inhibits RNA synthesis, an effect not seen with cytarabine.

Display Name: Elacytarabine

Label: Elacytarabine

NCI Thesaurus Code: C53401 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1707141  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-amino-1-[5-O-[(9E)-octadec-9-enoyl]-beta-D-arabinofuranosyl]pyrimidin-2(1H)-one
CP-4055
Elacyt
Elacytarabine
ELACYTARABINE

External Source Codes: 
CAS Registry Number 188181-42-2 (see NLM ChemIDplus info)
CAS Registry Number 675837-43-1 (see NLM ChemIDplus info)
FDA UNII Code TA7WJG93AR
PDQ Closed Trial Search ID 463939
PDQ Open Trial Search ID 463939 (check for NCI PDQ open clinical trial info)
UMLS CUI C1707141

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C27H45N3O6
code C53401
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CP-4055
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53401

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