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National Cancer Institute
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Version: 17.10e (Release date: 2017-10-30)
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ADH-1 (Code C53399)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: ADH-1

Definition: A small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels.

Display Name: ADH-1

Label: ADH-1

NCI Thesaurus Code: C53399 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1706644  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 462569
PDQ Open Trial Search ID 462569 (check for NCI PDQ open clinical trial info)
UMLS CUI C1706644

Other Properties:
     Name Value (qualifiers indented underneath)
code C53399
Contributing_Source CTRP
Legacy_Concept_Name ADH-1
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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