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National Cancer Institute
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Version: 16.11d (Release date: 2016-11-28)
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ADH-1 (Code C53399)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: ADH-1

Definition: A small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels.

Display Name: ADH-1

Label: ADH-1

NCI Thesaurus Code: C53399 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1706644  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ADH-1
Exherin

External Source Codes: 
PDQ Closed Trial Search ID 462569
PDQ Open Trial Search ID 462569 (check for NCI PDQ open clinical trial info)
UMLS CUI C1706644

Other Properties:
Name Value (qualifiers indented underneath)
code C53399
Contributing_Source CTRP
Legacy_Concept_Name ADH-1
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53399

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