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Version: 17.06d (Release date: 2017-06-26)
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Brivanib Alaninate (Code C53397)

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Terms & Properties

Preferred Name: Brivanib Alaninate

Definition: The alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. Brivanib alaninate may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor 2 inhibitor and a type of antiangiogenesis agent.

Display Name: Brivanib Alaninate

Label: Brivanib Alaninate

NCI Thesaurus Code: C53397 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1701190  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-582664
BMS 582664
Brivanib Alaninate
brivanib alaninate
BRIVANIB ALANINATE

External Source Codes: 
CAS Registry Number 649735-63-7 (see NLM ChemIDplus info)
FDA UNII Code U2Y5OFN795
PDQ Closed Trial Search ID 462556
PDQ Open Trial Search ID 462556 (check for NCI PDQ open clinical trial info)
UMLS CUI C1701190

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H24FN5O4
code C53397
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name BMS-582664
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53397

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