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Version: 16.10e (Release date: 2016-10-31)
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Guanazole (Code C531)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Guanazole

Definition: A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase activity and DNA synthesis. (NCI04)

Label: Guanazole

NCI Thesaurus Code: C531 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0018316  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-1,2,4-Triazole-3,5-Diamine
3,5-Diamino-1H-1,2,4-Triazole
GUANAZOLE
Guanazole
MC 51762
S-Triazole, 3,5-Diamino-

External Source Codes: 
CAS Registry Number 1455-77-2 (see NLM ChemIDplus info)
FDA UNII Code I01TWM5267
NSC Code 166592 (see NCI DTP info)
NSC Code 167391 (see NCI DTP info)
NSC Code 167392 (see NCI DTP info)
NSC Code 1895 (see NCI DTP info)
PDQ Closed Trial Search ID 39252
PDQ Open Trial Search ID 39252 (check for NCI PDQ open clinical trial info)
UMLS CUI C0018316

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C2H5N5
code C531
Contributing_Source FDA
Legacy_Concept_Name Guanazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C531

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