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Version: 17.06d (Release date: 2017-06-26)
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Gossypol (Code C529)

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Terms & Properties

Preferred Name: Gossypol

Definition: An orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive.

NCI-GLOSS Definition: A substance being studied in the treatment of several types of cancer. It comes from the seed of the cotton plant (Gossypium). It blocks the growth of cells and may kill cancer cells. Cottonseed meal toxin may also act as a male contraceptive (a type of birth control).

Label: Gossypol

NCI Thesaurus Code: C529 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0018096  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+/-)-Gossypol
(2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6'7, 7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-
1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3-3'-dimethyl[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
2,2'-bis(1,6,7-trihydroxy-4-methyl-5-isopropyl-8-aldehydonaphthalene)
2,2'-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]
BL-193
Cottonseed Meal Toxin
cottonseed meal toxin
Gossypol
GOSSYPOL
gossypol
No Fertil
Pogosin
Tash 1

External Source Codes: 
CAS Registry Number 303-45-7 (see NLM ChemIDplus info)
FDA UNII Code KAV15B369O
ChEBI ID CHEBI:28584 (see ChEBI info)
NSC Code 624336 (see NCI DTP info)
NSC Code 56817 (see NCI DTP info)
PDQ Closed Trial Search ID 505287
PDQ Open Trial Search ID 505287 (check for NCI PDQ open clinical trial info)
UMLS CUI C0018096

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H30O8
code C529
Contributing_Source FDA
Legacy_Concept_Name Gossypol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C529

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