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Version: 17.06d (Release date: 2017-06-26)
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Glutathione (Code C523)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Glutathione

Definition: A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes.

NCI-GLOSS Definition: A substance found in plant and animal tissues that has many functions in a cell. These include activating certain enzymes and destroying toxic compounds and chemicals that contain oxygen.

Display Name: Glutathione

Label: Glutathione

NCI Thesaurus Code: C523 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0017817  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Glutathione
glutathione
GLUTATHIONE
Glutham
GSH
N-(N-L-gamma-glutamyl-L-cysteinyl)glycine
Reduced Glutathione

External Source Codes: 
CAS Registry Number 70-18-8 (see NLM ChemIDplus info)
FDA UNII Code GAN16C9B8O
ChEBI ID CHEBI:16856 (see ChEBI info)
NSC Code 400639 (see NCI DTP info)
PDQ Closed Trial Search ID 655232
PDQ Open Trial Search ID 655232 (check for NCI PDQ open clinical trial info)
UMLS CUI C0017817

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H17N3O6S
code C523
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Glutathione
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Biologically Active Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C523

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