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Version: 17.06d (Release date: 2017-06-26)
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Glutamine (Code C522)

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Terms & Properties

Preferred Name: Glutamine

Definition: A nonessential amino acid. Glutamine can donate the ammonia on its side chain to the formation of urea (for eventual excretion by the kidneys) and to purines (necessary for the synthesis of nucleic acids). Glutamic acid-to-glutamine conversion, in which an ammonia group is added to glutamic acid (catalyzed by glutamine synthase), is of central importance in the regulation of toxic levels of ammonia in the body. This agent is a substrate for the production of both excitatory and inhibitory neurotransmitters (glutamate and GABA) and is also an important source of energy for the nervous system. Glutamine may become a conditionally essential amino acid during certain catabolic states.

CRCH Definition: Amino acid with side chain -CH2CH2CONH2.

NCI-GLOSS Definition: An amino acid used in nutrition therapy. It is also being studied for the treatment of diarrhea caused by radiation therapy to the pelvis.

Display Name: Glutamine

Label: Glutamine

NCI Thesaurus Code: C522 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0017797  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S)-2-Aminopentane-dioic acid 5-amide
Q. Levoglutamide
Resource Glutasolve
Sympt-X G.I.

External Source Codes: 
CAS Registry Number 56-85-9 (see NLM ChemIDplus info)
FDA UNII Code 0RH81L854J
ChEBI ID CHEBI:18050 (see ChEBI info)
NSC Code 27421 (see NCI DTP info)
PDQ Closed Trial Search ID 42298
PDQ Open Trial Search ID 42298 (check for NCI PDQ open clinical trial info)
UMLS CUI C0017797

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Short bowel syndrome
Chemical_Formula C5H10N2O3
code C522
Contributing_Source CRCH
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Glutamine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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