|Glutamine (Code C522)|
|Terms & Properties|
Preferred Name: Glutamine
Definition: A nonessential amino acid. Glutamine can donate the ammonia on its side chain to the formation of urea (for eventual excretion by the kidneys) and to purines (necessary for the synthesis of nucleic acids). Glutamic acid-to-glutamine conversion, in which an ammonia group is added to glutamic acid (catalyzed by glutamine synthase), is of central importance in the regulation of toxic levels of ammonia in the body. This agent is a substrate for the production of both excitatory and inhibitory neurotransmitters (glutamate and GABA) and is also an important source of energy for the nervous system. Glutamine may become a conditionally essential amino acid during certain catabolic states.
CRCH Definition: Amino acid with side chain -CH2CH2CONH2.
NCI-GLOSS Definition: An amino acid used in nutrition therapy. It is also being studied for the treatment of diarrhea caused by radiation therapy to the pelvis.
Display Name: Glutamine
NCI Metathesaurus Link: C0017797 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
|(S)-2-Aminopentane-dioic acid 5-amide|
External Source Codes:
|CAS Registry Number||56-85-9 (see NLM ChemIDplus info)|
|FDA UNII Code||0RH81L854J|
|ChEBI ID||CHEBI:18050 (see ChEBI info)|
|NSC Code||27421 (see NCI DTP info)|
|PDQ Closed Trial Search ID||42298|
|PDQ Open Trial Search ID||42298 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
|Accepted_Therapeutic_Use_For||Short bowel syndrome|
|Semantic_Type||Amino Acid, Peptide, or Protein|
Additional Concept Data:
|Defined Fully by Roles: No|