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National Cancer Institute
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Version: 16.10e (Release date: 2016-10-31)
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SB-743921 (Code C52199)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: SB-743921

Definition: A synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis.

Display Name: SB-743921

Label: SB-743921

NCI Thesaurus Code: C52199 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1709979  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
SB-743921

External Source Codes: 
PDQ Closed Trial Search ID 456262
PDQ Open Trial Search ID 456262 (check for NCI PDQ open clinical trial info)
UMLS CUI C1709979

Other Properties:
Name Value (qualifiers indented underneath)
code C52199
Contributing_Source CTRP
Legacy_Concept_Name SB-743921
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52199

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