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Version: 17.06d (Release date: 2017-06-26)
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Ropivacaine Hydrochloride (Code C52198)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ropivacaine Hydrochloride

Definition: The hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. Ropivacaine binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions and resulting in a stabilization of the neuronal membrane and inhibition of depolarization; nerve impulse generation and propagation are blocked, resulting in a reversible loss of sensation.

NCI-GLOSS Definition: A drug used to control pain and to cause a temporary loss of feeling in one part of the body, during and after surgery. It is also being studied for pain control after cancer surgery. It is a type of local anesthetic.

Display Name: Ropivacaine Hydrochloride

Label: Ropivacaine Hydrochloride

NCI Thesaurus Code: C52198 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0771826  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S)-(-)-1-Propylpiperidine-2-carboxylic acid (2,6-dimethylphenyl)amide Hydrochloride Monohydrate
Naropin
Ropivacaine Hydrochloride
ROPIVACAINE HYDROCHLORIDE
ropivacaine hydrochloride
Ropivacaine Hydrochloride Monohydrate
S-(-)-1-propyl-2,6-pipecoloxylidide Hydrochloride Monohydrate

External Source Codes: 
CAS Registry Number 132112-35-7 (see NLM ChemIDplus info)
FDA UNII Code V910P86109
ChEBI ID CHEBI:34954 (see ChEBI info)
PDQ Closed Trial Search ID 459953
PDQ Open Trial Search ID 459953 (check for NCI PDQ open clinical trial info)
UMLS CUI C0771826

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C17H26N2O.HCl.H2O
code C52198
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ropivicaine_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52198

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