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Version: 17.06d (Release date: 2017-06-26)
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Carfilzomib (Code C52196)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Carfilzomib

Definition: An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.

Display Name: Carfilzomib

Label: Carfilzomib

NCI Thesaurus Code: C52196 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1709429  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S)-N-((1S)-1-Benzyl-2-(((1S)-3-methyl-1-(((2R)-2-methyloxiran-2-yl)carbonyl)butyl)amino)-2-oxoethyl)-4-methyl-2-(((2S)-2-((morpholin-4-ylacetyl)amino)-4-phenylbutanoyl)amino)pentanamide
Carfilzomib
CARFILZOMIB
Kyprolis
PR-171

External Source Codes: 
CAS Registry Number 868540-17-4 (see NLM ChemIDplus info)
FDA UNII Code 72X6E3J5AR
PDQ Closed Trial Search ID 459751
PDQ Open Trial Search ID 459751 (check for NCI PDQ open clinical trial info)
UMLS CUI C1709429

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C40H57N5O7
code C52196
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PR-171
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52196

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