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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Carfilzomib (Code C52196)

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Terms & Properties

Preferred Name: Carfilzomib

Definition: An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.

Display Name: Carfilzomib

Label: Carfilzomib

NCI Thesaurus Code: C52196 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1709429  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 868540-17-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 459751
PDQ Open Trial Search ID 459751 (check for NCI PDQ open clinical trial info)
UMLS CUI C1709429

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C40H57N5O7
code C52196
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PR-171
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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