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Version: 17.06d (Release date: 2017-06-26)
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PD0325901 (Code C52195)

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Terms & Properties

Preferred Name: PD0325901

Definition: An orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.

Display Name: PD0325901

Label: PD0325901

NCI Thesaurus Code: C52195 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1675748  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PD-0325901
PD0325901

External Source Codes: 
FDA UNII Code 86K0J5AK6M
PDQ Closed Trial Search ID 456780
PDQ Open Trial Search ID 456780 (check for NCI PDQ open clinical trial info)
UMLS CUI C1675748

Other Properties:
     Name Value (qualifiers indented underneath)
code C52195
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PD-0325901
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52195

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