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Version: 17.06d (Release date: 2017-06-26)
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Levonorgestrel-Releasing Intrauterine System (Code C52193)

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Terms & Properties

Preferred Name: Levonorgestrel-Releasing Intrauterine System

Definition: A long-acting, hormone-releasing, intrauterine device consisting of a small, T-shaped, polyethylene frame and a reservoired synthetic progesterone with progestational and potential antineoplastic activities. After insertion of this system into the uterus, the device slowly and gradually releases the hormone. Levonorgestrel acts by binding to the progesterone receptor in the nuclei of target cells, resulting in transcription activation and an alteration in protein synthesis. Subsequently, luteinizing hormone (LH) activity and ovulation are suppressed. Levonorgestrel may also exhibit antiproliferative activity in endometrial tissue.

Display Name: Levonorgestrel-Releasing Intrauterine System

Label: Levonorgestrel-Releasing Intrauterine System

NCI Thesaurus Code: C52193 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0591811  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Levonorgestrel-Releasing Intrauterine System
Mirena

External Source Codes: 
PDQ Closed Trial Search ID 459975
PDQ Open Trial Search ID 459975 (check for NCI PDQ open clinical trial info)
UMLS CUI C0591811

Other Properties:
     Name Value (qualifiers indented underneath)
code C52193
Contributing_Source CTRP
Legacy_Concept_Name Levonorgestrel-Releasing_Intrauterine_System
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52193

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