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Version: 17.08d (Release date: 2017-08-28)
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GM-K562 Cell Vaccine (Code C52190)

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Terms & Properties

Preferred Name: GM-K562 Cell Vaccine

Definition: A cell-based vaccine comprised of K562 cells transfected with the granulocyte macrophage-colony stimulating factor (GM-CSF) gene with potential immunopotentiating properties. Vaccination with GM-K562 cells may stimulate the host immune system to produce an antitumoral T-lymphocyte response, thereby inhibiting tumor growth. K562 cells are derived from the human erythroleukemia cell line K562. GM-CSF (also known as sagramostim) expressed by vaccine cells binds to specific cell surface receptors, modulating the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production. GM-CSF also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity.

Display Name: GM-K562 Cell Vaccine

Label: GM-K562 Cell Vaccine

NCI Thesaurus Code: C52190 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1708127  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GM-K562 Cell Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 460926
PDQ Open Trial Search ID 460926 (check for NCI PDQ open clinical trial info)
UMLS CUI C1708127

Other Properties:
     Name Value (qualifiers indented underneath)
code C52190
Contributing_Source CTRP
Legacy_Concept_Name GM-K562_Cell_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52190

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