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Version: 17.06d (Release date: 2017-06-26)
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Romiplostim (Code C52183)

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Terms & Properties

Preferred Name: Romiplostim

Definition: A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets.

NCI-GLOSS Definition: A drug used to treat patients with immune thrombocytopenic purpura (ITP) who do not get better with other forms of treatment. In ITP, platelets (cells that cause blood clots to form) are destroyed by the immune system. Romiplostim is being studied as a way to treat low platelet counts caused by chemotherapy. It binds to the thrombopoietin receptor and causes the bone marrow to make more platelets. Romiplostim is also being studied in the treatment of myelodysplastic syndromes (a group of diseases in which the bone marrow does not make enough healthy blood cells). It is a type of thrombopoietin agonist.

Display Name: Romiplostim

Label: Romiplostim

NCI Thesaurus Code: C52183 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2364481  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Amgen Megakaryopoiesis Protein 2
AMG 531
Nplate
Romiplostim
romiplostim
ROMIPLOSTIM

External Source Codes: 
CAS Registry Number 267639-76-9 (see NLM ChemIDplus info)
FDA UNII Code GN5XU2DXKV
PDQ Closed Trial Search ID 459753
PDQ Open Trial Search ID 459753 (check for NCI PDQ open clinical trial info)
UMLS CUI C2364481

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For chronic immune thrombocytopenic purpura
code C52183
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name AMG531
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52183

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