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Version: 17.06d (Release date: 2017-06-26)
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Oxitriptan (Code C52181)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oxitriptan

Definition: An aromatic amino acid with antidepressant activity. In vivo, oxitriptan (or 5-hydroxytryptophan) is converted into 5-hydroxytryptamine (5-HT or serotonin) as well as other neurotransmitters. Oxitriptan may exert its antidepressant activity via conversion to serotonin or directly by binding to serotonin (5-HT) receptors within the central nervous system (CNS). Endogenous oxitriptan is produced from the essential amino acid L-tryptophan. The exogenous therapeutic form is isolated from the seeds of the African plant Griffonia simplicifolia.

Label: Oxitriptan

NCI Thesaurus Code: C52181 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0000578  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Amino-3-(5-hydroxy-1-H-indol-3-yl)propionic Acid
5-HTP
5-Hydroxytryptophan
L-5-Hydroxytryptophan
Levothym
OXITRIPTAN
Oxitriptan
Oxyfan
Pretonine
Quietim
Serotonyl
Telesol

External Source Codes: 
CAS Registry Number 4350-09-8 (see NLM ChemIDplus info)
FDA UNII Code C1LJO185Q9
ChEBI ID CHEBI:17780 (see ChEBI info)
NSC Code 92523 (see NCI DTP info)
PDQ Closed Trial Search ID 459776
PDQ Open Trial Search ID 459776 (check for NCI PDQ open clinical trial info)
UMLS CUI C0000578

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C11H12N2O3
code C52181
Contributing_Source FDA
Legacy_Concept_Name _5-Hydroxytryptophan
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52181

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