|18F-Fluoromisonidazole (Code C52180)|
|Terms & Properties|
Preferred Name: 18F-Fluoromisonidazole
Definition: A radiofluorinated 2-nitroimidazole derivate with hypoxia-specific tracer activity. Misonidazole is reduced under hypoxic conditions and in reduced form covalently binds to macromolecules in hypoxic cells. 18F (fluorine-18) radiofluorination of misonidazole to form 18F-fluoromisonidazole allows radioisotopic imaging of reduced misonidazole bound to macromolecules in hypoxic cells.
NCI-GLOSS Definition: A radioactive substance being studied as an imaging agent in head and neck cancers and other types of cancer. It binds to large molecules in tumor cells that have a low level of oxygen. Radiation given off by 18F-fluoromisonidazole is detected by a PET scan. The amount of 18F-fluoromisonidazole in the tumor may help decide the best treatment and help predict whether the cancer will come back after treatment. 18F-fluoromisonidazole is a type of radioimaging agent.
Display Name: 18F-Fluoromisonidazole
NCI Metathesaurus Link: C1710834 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|PDQ Closed Trial Search ID||458064|
|PDQ Open Trial Search ID||458064 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|