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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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18F-Fluoromisonidazole (Code C52180)

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Terms & Properties

Preferred Name: 18F-Fluoromisonidazole

Definition: A radiofluorinated 2-nitroimidazole derivate with hypoxia-specific tracer activity. Misonidazole is reduced under hypoxic conditions and in reduced form covalently binds to macromolecules in hypoxic cells. 18F (fluorine-18) radiofluorination of misonidazole to form 18F-fluoromisonidazole allows radioisotopic imaging of reduced misonidazole bound to macromolecules in hypoxic cells.

NCI-GLOSS Definition: A radioactive substance being studied as an imaging agent in head and neck cancers and other types of cancer. It binds to large molecules in tumor cells that have a low level of oxygen. Radiation given off by 18F-fluoromisonidazole is detected by a PET scan. The amount of 18F-fluoromisonidazole in the tumor may help decide the best treatment and help predict whether the cancer will come back after treatment. 18F-fluoromisonidazole is a type of radioimaging agent.

Display Name: 18F-Fluoromisonidazole

Label: 18F-Fluoromisonidazole

NCI Thesaurus Code: C52180 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1710834  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 458064
PDQ Open Trial Search ID 458064 (check for NCI PDQ open clinical trial info)
UMLS CUI C1710834

Other Properties:
     Name Value (qualifiers indented underneath)
code C52180
Contributing_Source CTRP
Legacy_Concept_Name _18F-Misonidazole
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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