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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Broccoli Sprout Extract (Code C52174)

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Terms & Properties

Preferred Name: Broccoli Sprout Extract

Definition: A cruciferous vegetable extract with potential chemopreventive activities. Broccoli sprout extract contains a high amount of sulforaphane, a naturally occurring isothiocyanate. Sulforaphane activates the transcription factor NF-E2-related factor 2 (Nrf2), a member of the basic leucine zipper family, which binds to and activates antioxidant-response elements (AREs). Subsequently, activated AREs mediate the transcription of antioxidant enzymes (particularly glutathione-S-transferase and quinone oxidoreductase), resulting in the detoxification of highly reactive carcinogens. AREs are cis-acting regulatory enhancer elements found in the 5' flanking region of many phase II detoxification enzymes.

NCI-GLOSS Definition: A substance being studied in the prevention of cancer. Broccoli sprout extract comes from newly sprouted broccoli. It causes cells to make enzymes that may protect them against cancer-causing toxins in the body, and it may also block the growth of cancer cells.

Display Name: Broccoli Sprout Extract

Label: Broccoli Sprout Extract

NCI Thesaurus Code: C52174 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1707048  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Broccoli Sprout Extract
broccoli sprout extract

External Source Codes: 
PDQ Closed Trial Search ID 455271
PDQ Open Trial Search ID 455271 (check for NCI PDQ open clinical trial info)
UMLS CUI C1707048

Other Properties:
     Name Value (qualifiers indented underneath)
code C52174
Contributing_Source CTRP
Legacy_Concept_Name Broccoli_Sprout_Extract
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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