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Version: 17.06d (Release date: 2017-06-26)
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Ganciclovir (Code C517)

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Terms & Properties

Preferred Name: Ganciclovir

Definition: A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation.

NCI-GLOSS Definition: An antiviral agent used to prevent or treat cytomegalovirus infections that may occur when the body's immune system is suppressed. In gene therapy, ganciclovir is used with an altered herpes simplex virus-1 gene to kill advanced melanoma cells and brain tumor cells.

Display Name: Ganciclovir

Label: Ganciclovir

NCI Thesaurus Code: C517 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0017066  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2'-Nor-2'-deoxyguanosine
2'NDG
2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one
9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
Cymevan
DHPG
Ganciclovir
GANCICLOVIR
ganciclovir
GCV
Nordeoxyguanosine
Virgan

External Source Codes: 
CAS Registry Number 82410-32-0 (see NLM ChemIDplus info)
FDA UNII Code P9G3CKZ4P5
ChEBI ID CHEBI:465284 (see ChEBI info)
NSC Code 716361 (see NCI DTP info)
PDQ Closed Trial Search ID 40565
PDQ Open Trial Search ID 40565 (check for NCI PDQ open clinical trial info)
UMLS CUI C0017066

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cytomegalovirus (CMV) Infections in Immunocompromised Patients.
Chemical_Formula C9H13N5O4
code C517
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ganciclovir
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C517

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