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Version: 17.06d (Release date: 2017-06-26)
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Tegafur (Code C513)

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Terms & Properties

Preferred Name: Tegafur

Definition: A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called antimetabolites.

Label: Tegafur

NCI Thesaurus Code: C513 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0016778  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione
5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-(1H,3H)-pyrimidinedione
5-Fluoro-1-(tetrahydro-2-furyl)-uracil
Citofur
Coparogin
Exonal
Fental
Florafur
Fluorofur
FT
FT-207
Ftorafur
Ftoral
Ftoralon
Fulaid
Fulfeel
Furafluor
Furofutran
Futraful
Lamar
Lifril
MJF-12264
N1-(2'-Furanidyl)-5-fluorouracil
Neberk
Nitobanil
Riol
Sinoflurol
Sunfural
Tefsiel
Tegafur
tegafur
TEGAFUR
Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-
Utefos
WR-220066

External Source Codes: 
CAS Registry Number 17902-23-7 (see NLM ChemIDplus info)
FDA UNII Code 1548R74NSZ
NSC Code 148958 (see NCI DTP info)
PDQ Closed Trial Search ID 39248
PDQ Open Trial Search ID 39248 (check for NCI PDQ open clinical trial info)
UMLS CUI C0016778

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H9FN2O3
code C513
Contributing_Source FDA
Legacy_Concept_Name Tegafur
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C513

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