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Version: 17.10e (Release date: 2017-10-30)
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Folic Acid (Code C510)

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Terms & Properties

Preferred Name: Folic Acid

Definition: A collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions of amino acid metabolism, in addition to purine and pyrimidine synthesis, and is essential for hematopoiesis and red blood cell production. (NCI05)

NCI-GLOSS Definition: A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Folate helps to make red blood cells. It is found in whole-grain breads and cereals, liver, green vegetables, orange juice, lentils, beans, and yeast. Folate is water-soluble (can dissolve in water) and must be taken in every day. Not enough folate can cause anemia (a condition in which the number of red blood cells is below normal), diseases of the heart and blood vessels, and defects in the brain and spinal cord in a fetus. Folate is being studied with vitamin B12 in the prevention and treatment of cancer.

CRCH Definition: Synthetic folate in fortified foods and supplements containing a single glutamate molecule.

Display Name: Folic Acid

Label: Folic Acid

NCI Thesaurus Code: C510 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0016410  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid
Folic Acid
folic acid
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid
Pteroylmonoglutamic Acid
Vitamin B9
Vitamin Bc

External Source Codes: 
CAS Registry Number 59-30-3 (see NLM ChemIDplus info)
FDA UNII Code 935E97BOY8
ChEBI ID CHEBI:27470 (see ChEBI info)
NSC Code 3073 (see NCI DTP info)
PDQ Closed Trial Search ID 39641
PDQ Open Trial Search ID 39641 (check for NCI PDQ open clinical trial info)
UMLS CUI C0016410

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H19N7O6
code C510
Contributing_Source CRCH
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Folic_Acid
Semantic_Type Organic Chemical
Semantic_Type Vitamin
Tolerable_Level Y
Unit mcg
US_Recommended_Intake Y* (*for women of childbearing age)

Additional Concept Data: 
Defined Fully by Roles: No  


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