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Version: 17.06d (Release date: 2017-06-26)
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Flutamide (Code C509)

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Terms & Properties

Preferred Name: Flutamide

Definition: A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)

NCI-GLOSS Definition: An anticancer drug that is a type of antiandrogen.

Display Name: Flutamide

Label: Flutamide

NCI Thesaurus Code: C509 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0016384  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
4'-Nitro-3'-trifluoromethylisobutyranilide
Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide
Apimid
Cebatrol
Chimax
Cytomid
Drogenil
Euflex
Eulexin
Eulexine
Flucinom
Flucinome
Flugerel
Fluken
Flulem
FLUT
Fluta-Gry
Flutabene
Flutacan
Flutamex
Flutamide
FLUTAMIDE
flutamide
Flutamin
Flutan
Flutaplex
Fugerel
Grisetin
Niftolide
Oncosal
Profamid
Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
Prostacur
Prostadirex
Prostica
Prostogenat
Sch 13521
SCH 13521
Tafenil
Tecnoflut
Testotard

External Source Codes: 
CAS Registry Number 13311-84-7 (see NLM ChemIDplus info)
FDA UNII Code 76W6J0943E
ChEBI ID CHEBI:5132 (see ChEBI info)
NSC Code 147834 (see NCI DTP info)
NSC Code 215876 (see NCI DTP info)
PDQ Closed Trial Search ID 39811
PDQ Open Trial Search ID 39811 (check for NCI PDQ open clinical trial info)
UMLS CUI C0016384

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hirsutism; Prostate carcinoma
Chemical_Formula C11H11F3N2O3
code C509
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Flutamide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C509

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