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Version: 17.06d (Release date: 2017-06-26)
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Flurbiprofen (Code C508)

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Terms & Properties

Preferred Name: Flurbiprofen

Definition: A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure.

Label: Flurbiprofen

NCI Thesaurus Code: C508 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0016377  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid
Ansaid
BTS 18,322
FLURBIPROFEN
Flurbiprofen
U-27,182

External Source Codes: 
CAS Registry Number 5104-49-4 (see NLM ChemIDplus info)
FDA UNII Code 5GRO578KLP
ChEBI ID CHEBI:5130 (see ChEBI info)
NSC Code 685701 (see NCI DTP info)
PDQ Closed Trial Search ID 39245
PDQ Open Trial Search ID 39245 (check for NCI PDQ open clinical trial info)
UMLS CUI C0016377

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H13FO2
code C508
Contributing_Source FDA
Legacy_Concept_Name Flurbiprofen
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C508

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