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Version: 16.11d (Release date: 2016-11-28)
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Fluorouracil (Code C505)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluorouracil

Definition: An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions.

NCI-GLOSS Definition: A drug used to treat symptoms of cancer of the colon, breast, stomach, and pancreas. It is also used in a cream to treat certain skin conditions. Fluorouracil stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite.

Display Name: Fluorouracil

Label: Fluorouracil

NCI Thesaurus Code: C505 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0016360  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2,4-Dioxo-5-fluoropyrimidine
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoro-2,4(1H, 3H)-pyrimidinedione
5-Fluorouracil
5-fluorouracil
5-Fluracil
5-FU
5-Fu
AccuSite
Adrucil
Carac
Fluorouracil
FLUOROURACIL
fluorouracil
Fluoro Uracil
Fluouracil
Flurablastin
Fluracedyl
Fluracil
Fluril
Fluroblastin
Ribofluor
Ro-2-9757
Ro 2-9757

External Source Codes: 
CAS Registry Number 51-21-8 (see NLM ChemIDplus info)
FDA UNII Code U3P01618RT
ChEBI ID CHEBI:46345 (see ChEBI info)
NSC Code 19893 (see NCI DTP info)
PDQ Closed Trial Search ID 43130
PDQ Open Trial Search ID 43130 (check for NCI PDQ open clinical trial info)
UMLS CUI C0016360

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Palliative treatment: Colorectal cancer, Breast cancer, Stomach cancer, Pancreatic cancer. Topical treatment for the following: Superficial basal cell carcinoma that cannot be treated with surgery, and Actinic keratosis.
Chemical_Formula C4H3FN2O2
code C505
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fluorouracil
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C505

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